Porphyrin Derivatives-Mediated Sonodynamic Therapy for Malignant Gliomas In Vitro
نویسندگان
چکیده
منابع مشابه
Gene Therapy for Malignant Gliomas
Retroviruses are enveloped RNA viruses that possess the ability to integrate into the host cell genome by transcribing DNA from their RNA template via viral reverse transcriptase. The transcribed viral DNA is then integrated into the host cell genome nonspecifically. There is relative specificity for tumors because, except for lentiviruses, retroviral DNA preferentially integrates into the geno...
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Malignant gliomas are the most common intracranial tumors and are considered incurable. Therefore, exploration of novel therapeutic modalities is essential. Telomerase is a ribonucleoprotein enzyme that is detected in the vast majority of malignant gliomas but not in normal brain tissues. We, therefore, hypothesized that telomerase inhibition could be a very promising approach for the targeted ...
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Malignant gliomas are the most common neoplasm in the central nervous system. When treated with conventional treatments including surgery, irradiation, and chemotherapy, the average life expectancy of the most malignant type, glioblastoma multiforme is usually less than 1 year. Therefore, gene therapy is expected to be an effective and possibly curative treatment. Many gene therapeutic approach...
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BACKGROUND Inflammatory cells exhibit an elevated level of protoporphyrin IX (PpIX) after the administration of 5-aminolevulinic acid (ALA). Here, we investigate the sonodynamic effects of ALA-derived PpIX (ALA-PpIX) on macrophages, which are the pivotal inflammatory cells in atherosclerosis. METHODS AND RESULTS Cultured THP-1 macrophages were incubated with ALA. Fluorescence microscope and f...
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ژورنال
عنوان ژورنال: Ultrasound in Medicine & Biology
سال: 2015
ISSN: 0301-5629
DOI: 10.1016/j.ultrasmedbio.2015.05.007